大腸直腸藥物標的傳輸技術

複合醫材與藥品開發計畫

由於大腸直腸位於人體消化道的末端，口服治療大腸直腸疾病的藥物為了能達到較佳的治療效果，普遍的劑量都較高，導致具有很高的副作用，因此開發標的釋放藥物產品，將可以有效降低副作用，有其開發潛力。開發之產品藥物可以在0.1N HCl、pH 6.0 buffer中均不會釋出，在pH 7.5 buffer中藥物可以在2小時內快速釋出，此產品可以調控藥物在大腸(pH 7.5 buffer)的環境中藥物才會快速釋出，可以達到藥物標的釋放之目的。此技術將可以應用在需要在特殊環境釋出的藥物產品開發。

Since the colorectal is located at the distal end of the human digestive tract, oral administration of drugs that treat colorectal diseases in order to achieve better therapeutic effect, the general dose is higher, resulting in high side effects, so the development of the standard release drug products will be effective Reduce side effects, have their development potential. Developed products can not be released in 0.1N HCl, pH 6.0 buffer. The drug can be quickly released within 2 hours at pH 7.5 buffer. This product can regulate the drug in the environment of the large intestine (pH 7.5 buffer) The drug will be released quickly, you can achieve the purpose of the release of the drug standard. This technology will be developed for pharmaceutical products that need to be released in special circumstances.